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BOOK SUMMARY :

Drug resistance in leukemia remediation by natural means chittaranjan national cancer institute kolkata 700026 west bengal india madhumita roy apurba mukherjee sutapa mukherjee and jaydip biswas leukemia is a common cancer in the paediatric group with good prognosis and the overall survival rate for leukemia has improved over the yearsa key issue in the treatment of acute leukemia is the development of resistance to chemotherapeutic drugs several mechanisms may account for this phenomenon including failure of the cell to overcoming drug resistance in leukemia using a novel integrin alpha4 inhibito although many children who are treated for acute lymphoblastic leukemia all are cured a significant percentage is not and when this happens the prognosis is grima new mechanism of leukemia drug resistance clinical implications of basic research n engl j med 200735777 78 in the second sentence of the third paragraph page 77 generate and in this study we showed that a100a8 mediated autophagy is a significant contributor to drug resistance in leukemia we found that s100a8 level was elevated in drug resistance leukemia cells relative to the nondrug resistant cells and vincristine adriamycin and arsenic trioxide enhanced the expression of s100a8 in human leukemia cells

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