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Folate pathways are essential in metabolism and macromolecule synthesis antifolate drugs that are largely transported via a high capacity folate transporter ie the reduced folate carrier and inhibit folate dependent enzymes include the dihydrofolate reductase inhibitor methotrexate and the thymidylate synthase inhibitors raltitrexed and pemetrexedtargeting inammation in cancer prevention and therapy jelena todoric12 laura antonucci1 and michael karin13 abstract inammation is associated with the development and malig nant progression of most cancers as most of the cell types involved in cancer associated inammation are genetically sta the discoveries highlighted in this book parallel the emergence of innovative molecular targeted small molecules and monoclonal antibodies ie agents that target proteins within highly activated syingjuan lu and christopher p leamon targeting activated macrophages via a functional folate receptor for potential treatment of autoimmuneinflammatory disorders targeted drug strategies for cancer and inflammation 101007978 1 4419 8417 3 10 195 216 2011read targeted drug strategies for cancer and inflammation by available from rakuten kobo sign up today and get 5 off your first purchase folate pathways are essential in metabolism and macromolecule synthesis antifolate drugs that are largely transported v

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